Non-coding RNAs are the key to gene regulation
Only 2% of the human genome codes for proteins yet the majority of the remaining 98% are also transcribed
The complexity of humans is due to the number and diversity of non-coding RNAs (not the number of genes)
Nuclear non-coding RNAs have been ignored
The nucleus is rich with non-coding RNAs which regulate chromatin and fine-tune gene expression
By targeting these nuclear non-coding RNAs, genes can be activated or silenced
Nucleus
Small RNAs can efficiently regulate gene expression
Targeting non-coding RNAs with small RNAs in the nucleus induces epigenetic changes on chromatin
This regulation of gene expression via small RNAs can result in long-lasting effects
